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Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
Hyaluronic acid "bruising" may be treated using injections of hyaluronidase enzyme around the location. [19] Other common medication-specific side effects include pain, burning or stinging, warmth, rash, flushing, or multiple of these reactions at the injection site, collectively termed "injection site reactions".
Purpura (purple) – a bruise about 3–5 mm in diameter, generally round in shape Ecchymosis – subcutaneous extravasation of blood in a thin layer under the skin, i.e. bruising or "black and blue", over 1 cm in diameter [ 3 ]
Mechanisms underlying the cause of reactogenicity symptoms. In clinical trials, reactogenicity is the capacity of a vaccine to produce common, "expected" adverse reactions, especially excessive immunological responses and associated signs and symptoms, including fever and sore arm at the injection site.
“Patients may experience long-lasting bruising, severe allergic reactions, skin necrosis due to product placement in blood vessels, or even permanent eye damage.” ... Mesotherapy and injection ...
The most common adverse effects of intercavernosal injections include fibrosis and pain, as well as hematomas or bruising around the injection site. [20] Medications may also be administered by injecting them directly into the vitreous humor of the eye.
How to Inject Semaglutide: A Step-by-Step Guide. Semaglutide, the active ingredient in Ozempic and Wegovy, is a glucagon-like peptide-1 (GLP-1) receptor agonist taken as a once-weekly injection.
Pain, redness, swelling or a hard lump at the injection site; Fever; Aching muscles, joint pain; Common (affects at least 1 in 100 people) Warmth, itching or bruising at the injection site; Increased sweating, shivering, flu-like symptoms; Swollen glands in the neck, armpit or groin; Uncommon (affects at least 1 in 1,000 people)