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Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2] Deaths from single-drug benzodiazepine overdoses occur infrequently, [3] particularly after the point of hospital admission. [4]
Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition. It was first characterized in 1981, [5] and was first marketed in 1987 by Hoffmann-La Roche under the trade name Anexate. However, it did not receive FDA approval until December 20, 1991.
The antidote for an overdose of diazepam (or any other benzodiazepine) is flumazenil (Anexate). This drug is only used in cases with severe respiratory depression or cardiovascular complications. This drug is only used in cases with severe respiratory depression or cardiovascular complications.
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The toxicity of benzodiazepine overdose and the risk of death are also increased in the elderly and those with obstructive pulmonary disease or when used intravenously. Treatment is supportive; activated charcoal can be used within an hour of the overdose. The antidote for an overdose of midazolam (or any other benzodiazepine) is flumazenil. [41]
An antidote is a substance that can counteract a form of poisoning. [1] ... Ethylene glycol poisoning and methanol poisoning: Flumazenil: Benzodiazepine overdose:
The death toll from fentanyl is falling as communities flood the streets with naloxone, an overdose-reversal drug. But deadly opioids remain rife. A fentanyl antidote is saving lives.
The various benzodiazepines differ in their toxicity; temazepam appears most toxic in overdose and when used with other drugs. [165] [166] The symptoms of a benzodiazepine overdose may include; drowsiness, slurred speech, nystagmus, hypotension, ataxia, coma, respiratory depression, and cardiorespiratory arrest. [163]