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Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. [4] [9] [10] The most common sign of infection is an expanding red rash, known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards. [1]
This rash was known as erythema chronicum migrans, the skin rash found in early-stage Lyme disease. [ 18 ] In the 1920s, French physicians Garin and Bujadoux described a patient with meningoencephalitis, painful sensory radiculitis, and erythema migrans following a tick bite, and they postulated the symptoms were due to a spirochetal infection.
Anywhere from 30,000 up to 500,000 people develop Lyme disease from a tick bite each year, according to the C DC. For most, the infection is mild and easily treated with antibiotics.
Chronic Lyme disease is distinct from untreated late-stage Lyme disease, which can cause arthritis, peripheral neuropathy and/or encephalomyelitis. Chronic Lyme disease is also distinct from post-treatment Lyme disease syndrome (PTLDS) when symptoms linger after standard antibiotic treatments.
If a bacterial infection goes untreated for too long, it can make you really sick. ... people with Lyme disease also report chills with no fever, says Dr. Quinlan. If you have a history of a tick ...
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The genomic variations have direct implications on the clinical symptoms of tick-borne Lyme disease. For example, B. burgdorferi s.s.’s tick-borne Lyme disease may manifest with arthritis-like symptoms. [9] In contrast, B. garinii’s tick-borne Lyme disease may cause an infection of the central nervous system. [9]
Eight are known to cause Lyme disease or Borreliosis. [6] The major Borrelia species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. [23] All species that cause Lyme disease are referred to collectively as B. burgdorferi sensu lato, [10] while B. burgdorferi itself is specified as B. burgdorferi sensu stricto.
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