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Blood free thyroxine and TSH levels are monitored to help determine whether the dose is adequate. This is done 4–8 weeks after the start of treatment or a change in levothyroxine dose. Once the adequate replacement dose has been established, the tests can be repeated after 6 and then 12 months, unless there is a change in symptoms. [ 8 ]
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible. The precise factor depends on hematocrit as well as amount inside RBCs.
Levothyroxine is also used to treat subclinical hypothyroidism, which is defined by an elevated TSH level and a normal-range free T 4 level without symptoms. [14] Such people may be asymptomatic [ 14 ] and whether they should be treated is controversial. [ 13 ]
TSH is the preferred initial test of thyroid function as it has a higher sensitivity to changes in thyroid status than free T 4. [ 60 ] Time of day can affect the results of this test; TSH peaks early in the morning and slumps in the late afternoon to early evening, [ 61 ] with "a variation in TSH by a mean of between 0.95 mIU/mL to 2.0 mIU/mL ...
In addition to testing the TSH levels, many doctors test for T 3, Free T 3, T 4, and/or Free T 4 for more detailed results. Free T 4 is unbound to any protein in the blood. Adult limits for these hormones are: TSH (units): 0.45 – 4.50 uIU/mL; T 4 Free/Direct (nanograms): 0.82 – 1.77 ng/dl; and T 3 (nanograms): 71 – 180 ng
In a significance test, the null hypothesis is rejected if the p-value is less than or equal to a predefined threshold value , which is referred to as the alpha level or significance level. α {\displaystyle \alpha } is not derived from the data, but rather is set by the researcher before examining the data.
It corresponds roughly to the intuitive notion of a fluid's 'thickness'. For instance, honey has a much higher viscosity than water. Viscosity is measured using a viscometer. Measured values span several orders of magnitude. Of all fluids, gases have the lowest viscosities, and thick liquids have the highest.
The local geometry of the universe is determined by whether the relative density Ω is less than, equal to or greater than 1. From top to bottom: a spherical universe with greater than critical density (Ω>1, k>0); a hyperbolic, underdense universe (Ω<1, k<0); and a flat universe with exactly the critical density (Ω=1, k=0).
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