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  2. microRNA - Wikipedia

    en.wikipedia.org/wiki/MicroRNA

    The double-stranded RNA (dsRNA) structure of the hairpins in a pri-miRNA is recognized by a nuclear protein known as DiGeorge Syndrome Critical Region 8 (DGCR8 or "Pasha" in invertebrates), named for its association with DiGeorge Syndrome. DGCR8 associates with the enzyme Drosha, a protein that cuts RNA, to form the Microprocessor complex.

  3. let-7 microRNA family - Wikipedia

    en.wikipedia.org/wiki/Let-7_microRNA_family

    The Let-7 microRNA precursor gives rise to let-7, a microRNA (miRNA) involved in control of stem-cell division and differentiation. [ 1 ] let-7 , short for "lethal-7", was discovered along with the miRNA lin-4 in a study of developmental timing in C. elegans , [ 2 ] making these miRNAs the first ever discovered.

  4. RNA-induced silencing complex - Wikipedia

    en.wikipedia.org/wiki/RNA-induced_silencing_complex

    The RISC-loading complex (RLC) is the essential structure required to load dsRNA fragments into RISC in order to target mRNA. The RLC consists of dicer, the transactivating response RNA-binding protein and Argonaute 2. Dicer is an RNase III endonuclease which generates the dsRNA fragments to be loaded that direct RNAi.

  5. Drosha - Wikipedia

    en.wikipedia.org/wiki/Drosha

    However, the exact nature of the association between microRNA processing and tumorigenesis is unclear, [21] but its function can be effectively examined by siRNA knockdown based on an independent validation. [22] Drosha and other miRNA processing enzymes may also be important in HIV-1 replication. miRNAs contribute to the innate antiviral defense.

  6. miR-155 - Wikipedia

    en.wikipedia.org/wiki/MiR-155

    406947 n/a Ensembl ENSG00000283904 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 25.57 – 25.57 Mb n/a PubMed search n/a Wikidata View/Edit Human MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes. [7] [8] [9] Exogenous molecular control in ...

  7. miR-324-5p - Wikipedia

    en.wikipedia.org/wiki/MiR-324-5p

    miR-324-5p is a reverse strand miRNA, meaning it is produced from the 5' end of the associated RNA, and spans from position 7,223,342 to 7,223,364 on chromosome 17. [14] Its sequence is CGCAUCCCCUAGGGCAUUGGUG. [15] [16] miRNA forms following cleavage of pre-miRNA at the hairpin loop by the enzyme dicer within the cytosol. Interestingly, both ...

  8. mir-15 microRNA precursor family - Wikipedia

    en.wikipedia.org/wiki/Mir-15_microRNA_precursor...

    The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. [1]

  9. MIR34A - Wikipedia

    en.wikipedia.org/wiki/MIR34A

    n/a Ensembl ENSG00000284357 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 9.15 – 9.15 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 34a (miR-34a) is a microRNA that in humans is encoded by the MIR34A gene. Function microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene ...

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