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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Unlike ticlopidine and clopidogrel, the activation of prasugrel involves hydrolysis to an intermediate thiolactone, which is then converted to the active metabolite in a single CYP-dependent step. The active metabolite, which is R-138727 (thiol intermediate), either binds irreversibly to the P2Y 12 receptor or is metabolic methylated to an ...
Blank samples taken before administration are important in determining background and ensuring data integrity with such complex sample matrices. Much attention is paid to the linearity of the standard curve; however it is common to use curve fitting with more complex functions such as quadratics since the response of most mass spectrometers is ...
Dementia prevention is a critical area of research, as experts want to understand what people can do to decrease dementia risk. A recent study found that more than 5 years of taking medications ...
Luigi Mangione, who authorities accuse of murdering UnitedHealthcare CEO Brian Thompson, allegedly wrote in a notebook that he considered bombing Manhattan to carry out the killing but did not ...
The biggest change people are noticing is anhedonia, or lack of interest in things they typically find pleasurable, says Michael Russo, MD, bariatric surgeon at MemorialCare Surgical Weight Loss ...
Clopidogrel, unlike prasugrel, was issued a black box warning from the FDA on 12 March 2010, as the estimated 2–14% of the US population who have low levels of the CYP2C19 liver enzyme needed to activate clopidogrel may not get the full effect. Tests are available to predict if a patient would be susceptible to this problem or not.
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