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Although there are over 50 identifiable hereditary forms of cancer, less than 0.3% of the population are carriers of a cancer-related genetic mutation and these make up less than 3–10% of all cancer cases. [3] The vast majority of cancers are non-hereditary ("sporadic cancers"). Hereditary cancers are primarily caused by an inherited genetic ...
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. [1] Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than the overall rate of cellular degradation (the destruction of biomolecules via the proteasome, lysosome or autophagy, or catabolism).
Otto Warburg postulated this change in metabolism is the fundamental cause of cancer, [7] a claim now known as the Warburg hypothesis. Today, mutations in oncogenes and tumor suppressor genes are thought to be responsible for malignant transformation , and the Warburg effect is considered to be a result of these mutations rather than a cause.
A newly identified colon cancer gene may drive the disease by making the environment in the vicinity of tumors more hospitable to them, researchers say. Why does colon cancer grow so fast? Study ...
The findings raise hope for more effective treatments for pancreatic cancer, which has a poor survival rate. Shutdown of crucial gene helps world’s deadliest cancer grow rapidly – study Skip ...
Scientists suggest the findings could one day allow doctors to use a blood test to predict how a patient’s cancer may progress. Genetic clues reveal how cancer might grow and spread – study ...
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
Colorectal cancer was traditionally a disease of the old, but no longer. Cancer of the rectum and large intestine is on a deadly march among people as young as age 20, with diagnosed cases ...