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Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring in more than 80% of polio infections. The symptoms are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.
Remarkably, there have been no toxic side effects with PVS-RIPO whatsoever, even at the highest possible dose (10 billion infectious virus particles). The potential value of PVSRIPO was the focus of a 2015 story on 60 Minutes. [4] In May 2016, the US Food and Drug Administration granted it breakthrough therapy designation for glioblastoma. [2]
For roughly 80 years, she has coped with the aftermath of a polio infection, including the late effects of polio, called post-polio syndrome. She now needs a wheelchair or mobility scooter to get ...
The distinct speciation of poliovirus probably occurred as a result of a change in cellular receptor specificity from intercellular adhesion molecule-1 (ICAM-1) (used by C-cluster Coxsackie A viruses) to CD155, leading to a change in pathogenicity and allowing the virus to infect nerve tissue. The mutation rate in the virus is relatively high ...
Polio is “shorthand for poliomyelitis, a disease of the central nervous system caused by infection with poliovirus,” Dr. Richard Lloyd, professor of molecular virology and microbiology at ...
Non-polio enteroviruses, like EV-D68, cause about 10 to 15 million infections and tens of thousands of hospitalizations each year across the US. EV-D68 was first identified in California in the ...
The virus is most often spread by person to person contact with the stool or saliva of the infected person. Two types of vaccines have been developed to prevent the occurrence and spread of the poliomyelitis virus. The first is an inactivated, or killed, form of the virus and the second is an attenuated, or weakened, form of the virus.