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Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
If Cushing's is suspected it can be confirmed via urinalysis of the creatine/cortisol ratio. L-thyroxine is the most common method of treating hypothyroidism in dogs, if used to treat a dog with Cushing's the dog will likely display polyuria and polydipsia and the condition may worsen. [13]
Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
Equine metabolic syndrome (EMS) is an endocrinopathy affecting horses and ponies. It is of primary concern due to its link to obesity, insulin dysregulation , and subsequent laminitis .
pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs
The young horse can become enthralled by something as simple as blowing air or a pile of dirt (his favorite to roll around in), which keeps Molly Jo on her toes. Clearly, there's never a dull day ...
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