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Pyrrole is an extremely weak base for an amine, with a conjugate acid pK a of −3.8. The most thermodynamically stable pyrrolium cation (C 4 H 6 N +) is formed by protonation at the 2 position. Substitution of pyrrole with alkyl substituents provides a more basic molecule—for example, tetramethylpyrrole has a conjugate acid pK a of +3.7.
Flatulence can be a problem for some dogs, which may be diet-related or a sign of gastrointestinal disease. This, in fact, may be the most commonly noticed source of odor from dogs fed cereal-based dog foods. Skunks and dogs often have aggressive encounters and a dog may be sprayed by a skunk. This results in an over-powering musky acrid odor ...
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