Search results
Results from the WOW.Com Content Network
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [ 1 ] [ 2 ] The metastasis typically shares a cancer cell type with the original site of the cancer. [ 3 ]
CNS metastasis is the spread and proliferation of cancer cells from their original tumour to form secondary tumours in portions of the central nervous system. [ 1 ] The process of tumour cells invading distant tissue is complex and obscure, but modern technology has permitted an enhanced detection of metastasis .
Brain metastasis can be single or multiple and involve any portion of the brain. Metastasis to dural structures generally occurs by hematogenous spread or direct invasion from a contiguous bone. Dural metastases can invade the underlying brain and cause focal edema and associated neurologic symptoms. These processes tend to cause seizures early ...
Secondary tumors of the brain are metastatic and have spread to the brain from cancers originating in another organ. Metastatic spread is usually by the blood. The most common types of cancers that spread to the brain are lung cancer (accounting for over half of all cases), breast cancer, melanoma skin cancer, kidney cancer and colon cancer. [62]
Lymphatic spread is the most common route of initial metastasis for carcinomas. [8] In contrast, it is uncommon for a sarcoma to metastasize via this route. Localized spread to regional lymph nodes near the primary tumor is not normally counted as a metastasis, although this is a sign of a worse outcome.
MRI of a patient with anaplastic astrocytoma. The WHO classification of tumours of the central nervous system is a World Health Organization Blue Book that defines, describes and classifies tumours of the central nervous system (CNS).
The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing, [1] in the elaboration of what turned out the first systematic classification of gliomas.
Metastasis occurs in about 39% of patients, most commonly to the lung. Features associated with poor prognosis include a large primary tumor (over 5 cm across), high grade disease, co-existent neurofibromatosis, and the presence of metastases. [5] It is a rare tumor type, with a relatively poor prognosis in children. [6]