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"Fluctuations in sex hormones can also cause coat changes in some dogs. In males, some testicular tumors can cause coat thinning and mammary gland enlargement." Endocrine disease: Symptoms
Estrogen also rises during pregnancy, and that, combined with progesterone, can contribute to the formation of melasma, which appears as dark brown spots or patches.
Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
Dog with atopic dermatitis, with signs around the eye created by rubbing. Atopy is a hereditary [3] and chronic (lifelong) allergic skin disease. Signs usually begin between 6 months and 3 years of age, with some breeds of dog, such as the golden retriever, showing signs at an earlier age.
Melasma is not totally preventable, especially if you’re predisposed, Dr. Finney says. But once it’s diagnosed and treated, there are some preventative measures that can prevent melasma flare-ups.
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
According to Dr. Wechsler, melasma typically manifests as dark brown, patch-like spots and can appear anywhere on the face—cheeks, forehead, and nose being most common (though it can strike near ...
The symptoms of melasma are dark, irregular, well-demarcated, hyperpigmented macules to patches. These patches often develop gradually over time. Melasma does not cause any other symptoms beyond the cosmetic discoloration. [4] Patches can vary in size from 0.5 cm (0.2 in) to larger than 10 cm (4 in) depending on the person.