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Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant (NaSSA), [11] although the actual evidence in support of this label has been regarded as poor. [17] It is a tetracyclic piperazine-azepine. [85] Mirtazapine has antihistamine, α 2-blocker, and antiserotonergic activity.
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
People may also be switched to the long-acting antidepressant fluoxetine, which can then be gradually decreased. [12] Approximately 20–50% of people who suddenly stop an antidepressant develop an antidepressant discontinuation syndrome. [187] [13] [188] The condition is generally not serious. [187]
Antidepressants could increase the risk of suicidal thoughts and behavior in people with depression under the age of 25. In 2004, the U.S. Food and Drug Administration along with the Neuro-Psychopharmacologic Advisory Committee and the Anti-Infective Drugs Advisory Committee, concluded that there was a causal link between newer antidepressants and pediatric suicidality. [7]
A study published in 2019 of more than 7,700 English adults over 50 found people who report experiencing ageism are more likely to say they are in poor health or have symptoms of depression.
Besides mirtazapine, they also block the α 1-adrenergic receptor [citation needed]. Conversely, whereas TCAs have relatively low affinity for the α 2 -adrenergic receptor , mianserin and mirtazapine potently antagonize this receptor, and this action is thought to be involved in their antidepressant effects [ citation needed ] .
The future of congressional investigations could be defined by Republican eagerness to probe private industry and less willingness to defer to the Justice Department, experts say. House ...
To look at the impact of levothyroxine use on a similar cohort of adults, in their latest research, the authors studied 32 males and 49 females who were aged 65 or over at the start of the study ...
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