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Fluorouracil (5-FU) is a skin cream or solution that treats skin cancer. It’s a chemotherapy agent that destroys cancer cells. Follow the instructions on the label to safely apply this cream or solution on your skin.
-Only the 5% cream or solution is recommended to treat superficial basal cell carcinoma. -Response starts with erythema, usually followed by vesiculation, desquamation, erosion and reepithelialization.
This medication is used on the skin to treat pre-cancerous and cancerous skin growths. Fluorouracil belongs to a class of medications known as anti-metabolites. It works by blocking the growth of...
For topical dosage form (cream and solution): For actinic or solar keratosis: Adults—Apply to the affected area 2 times a day for 2 to 4 weeks. Children—Use and dose must be determined by your doctor. For superficial basal cell carcinomas: Adults—Apply to the affected area 2 times a day for 3 to 6 weeks.
It's available as 5% topical cream and solution, and as 2% solution. Both strengths can treat actinic keratosis, a precancerous skin condition caused by exposure to ultraviolet (UV) light over time. But only fluorouracil 5% is approved to treat basal cell carcinoma, a type of skin cancer.
Five of 10 patients receiving Fluorouracil Cream USP, 0.5% (Microsphere) and nine of 10 patients receiving Fluorouracil Cream, 5% had measurable urine fluorouracil levels. Urine Pharmacokinetic Summary
Fluorouracil Cream USP contains 5% fluorouracil in a vanishing cream base consisting of methylparaben, polysorbate 60, propylene glycol, propylparaben, purified water, stearyl alcohol, and white petrolatum. Chemically, fluorouracil is a 5-fluoro-2,4 (1 H,3 H)-pyrimidinedione.
Fluorouracil Cream contains 5% w/w of fluorouracil USP in a cream base consisting of methylparaben, polysorbate 60, propylene glycol, propylparaben, purified water, stearyl alcohol and white petrolatum. Chemically, fluorouracil is 5-fluoro-2,4 (1 H,3 H)-pyrimidinedione.
Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [skin areas] caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used.
5% cream or solution: Apply 2 times a day in an amount sufficient to cover the lesions; continue until the inflammatory response reaches the erosion stage, then discontinue use; Duration of therapy: 3 to 6 weeks; however, therapy may be required for as long as 10 to 12 weeks before lesions are obliterated; Comments: