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Hyperlipidemia, hypertriglyceridemia, hypercholesterolemia. An atheroma, or atheromatous plaque, is an abnormal accumulation of material in the inner layer of an arterial wall. [1][2] The material consists of mostly macrophage cells, [3][4] or debris, containing lipids, calcium and a variable amount of fibrous connective tissue.
Atherosclerosis[ a ] is a pattern of the disease arteriosclerosis, [ 8 ] characterized by development of abnormalities called lesions in walls of arteries. This is a chronic inflammatory disease involving many different cell types, and driven by elevated levels of cholesterol in the blood. [ 9 ] These lesions may lead to narrowing of the ...
Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), [13] myocardial ischemia, [14] or simply heart disease, involves the reduction of blood flow to the cardiac muscle due to build-up of atherosclerotic plaque in the arteries of the heart. [5][6][15] It is the most common of the cardiovascular ...
Arteriosclerosis, literally meaning "hardening of the arteries", is an umbrella term for a vascular disorder characterized by abnormal thickening, hardening, and loss of elasticity [3] of the walls of arteries; [4] this process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis, which is a specific form of ...
Myocardial infarction; Other names: Acute myocardial infarction (AMI), heart attack: A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, causing catastrophic thrombus formation, totally occluding the artery and preventing blood flow downstream to the heart muscle.
Peripheral artery disease most commonly affects the legs, but other arteries may also be involved, such as those of the arms, neck, or kidneys. [4][17] Peripheral artery disease (PAD) is a form of peripheral vascular disease. Vascular refers to both the arteries and veins within the body. PAD differs from peripheral veinous disease.
Rupture of the plaque can release atherosclerotic debris or blood clots into the artery. A piece of this material can break off and travel ( embolize ) up through the internal carotid artery into the brain, where it blocks circulation, and can cause death of the brain tissue, a condition referred to as ischemic stroke .
However, the size of the atherosclerotic plaques detected were larger in the mice who had followed the early intermittent Western diet. This was also the case in female mice. This trend persisted ...
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