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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [6] For the prevention of cardiovascular disease, statins are a first-line treatment. [ 6 ]
The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear. [106] However, recent findings have indicated the inhibition of HMGCoAR as a key mechanism. [110] Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the hormone insulin. [106]
Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins. This group is responsible for ...
Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [ 1 ]
For Hubert Davis, it’s ‘Live Action’: Motivation behind the movement of UNC’s head coach. Andrew Carter. March 20, 2024 at 10:30 AM.
Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [3] [4] Generally it is used together with dietary changes and a statin. [5]
3.1 Mechanism of action. 3.2 Pharmacodynamics. 3.3 Pharmacokinetics. 4 ... In five RCTs a mean atorvastatin dose of 26 mg/day reduced LDL cholesterol by 44.0% and ...
In some literature articles, the terms "mechanism of action" and "mode of action" are used interchangeably, typically referring to the way in which the drug interacts and produces a medical effect. However, in actuality, a mode of action describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living ...