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A 3D cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments (e.g. a Petri dish), a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo. [1]
PDX models of glioblastoma (GBM) have been essential for improving our understanding of the disease both in preclinical and translational research. [29] In vitro cell culture models of glioblastoma, although valuable, can not fully replicate the complexity of the disease since there is a clear lack of the brain microenvironment and clonal ...
In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes , and microtiter ...
Because the world is much more complex than can be represented in a computer, all geospatial data are incomplete approximations of the world. [9] Thus, most geospatial data models encode some form of strategy for collecting a finite sample of an often infinite domain, and a structure to organize the sample in such a way as to enable interpolation of the nature of the unsampled portion.
Scientific modelling is an activity that produces models representing empirical objects, phenomena, and physical processes, to make a particular part or feature of the world easier to understand, define, quantify, visualize, or simulate.
[20] [21] Microfluidic BBB in vitro models replicate a 3D environment for embedded cells (which provides precise control of cellular and extracellular environment), replicate shear stress, have more physiologically relevant morphology in comparison to 2D models, and provide easy incorporation of different cell types into the device. [22]
On the other hand, the strict meaning of "tissue culture" refers to the culturing of tissue pieces, i.e. explant culture. Tissue culture is an important tool for the study of the biology of cells from multicellular organisms. It provides an in vitro model of the tissue in a well defined environment which can be easily manipulated and analysed ...
Definition of a three-dimensional mesh honoring the structural model to support volumetric representation of heterogeneity (see Geostatistics) and solving the Partial Differential Equations which govern physical processes in the subsurface (e.g. seismic wave propagation, fluid transport in porous media).