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Patients normally present with painless, swollen lymph nodes, often in the neck, armpit, or groin. [1] Some have swollen lymph nodes inside their body, such as in the chest or abdomen, which can go undetected until they become very large and cause symptoms like cough or abdominal pain.
Currently, standard treatment for T-cell acute lymphoblastic leukemia (T-ALL) involves long-term chemotherapy and medication to prevent or treat side effects associated with low white blood cell counts resulting from intensive chemotherapy regimens. The treatment typically occurs in three stages: induction, consolidation, and maintenance. [3]
The disease most commonly occurs in people over the age of 65, due to the accumulation of genetic mutations that occur over time. [3] [15] Men are diagnosed around twice as often as women (6.8 to 3.5 ratio). [16] It is much less common in people from Asia. [4] Five-year survival following diagnosis is approximately 83% in the United States. [3]
Coulier’s main symptom — severely swollen lymph nodes — is a common first sign of NHL, Barnett says. "The most common early sign of NHL is painless swelling of one or more lymph nodes, but ...
T-cell lymphoma which develops from the lymph nodes commonly causes symptoms as such swollen lymph nodes. [7] The swelling normally will not cause any pain and can be felt or seen as lumps on the surface of the skin. Nodal T-cell lymphoma subtypes such as peripheral T-cell lymphoma will often develop this symptom. [citation needed]
[3] [13] [14] Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy. [1] [2] Blood, urine, and bone marrow testing may also be useful in the diagnosis. [2] Medical imaging may then be done to determine if and where the cancer has spread. [1] [2] Lymphoma most often spreads to the lungs, liver, and brain. [1] [2]
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