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Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
Phenmetrazine has been used as an appetite suppressant for purposes of weight loss. [2] It was used therapeutically for this indication at a dosage of 25 mg two or three times per day (or 50–75 mg/day total) in adults. [2] Phenmetrazine has been found to produce similar weight loss to dextroamphetamine in people with obesity. [3]
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Due to high costs, some health plans in the US do not cover weight-loss drugs like semaglutide and tirzepatide. [74] [75] [76] In the United States, as of 2024, about half of private employer-sponsored plans cover these drugs, [77] Federal Medicare Part D does not, and only a few federally-funded, state-administered Medicaid plans do so. [78]
In the US, the drug label contains warnings for increased heart rate, suicidal behavior and ideation, glaucoma, mood and sleep disorders, creatinine elevation, and metabolic acidosis. Some of these warnings are based on historical observations in epilepsy patients taking topiramate.
Benzphetamine, sold under the brand name Didrex among others, is an amphetamine-type stimulant and appetite suppressant used short-term for weight loss along with a doctor-approved, reduced-calorie diet, exercise, and behavioral program. It is prescribed for obesity to people
Orlistat is used for the treatment of obesity.The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat.
Obesity medicine is a field of medicine dedicated to the comprehensive treatment of patients with obesity.Obesity medicine takes into account the multi-factorial etiology of obesity in which behavior, development, environment, epigenetic, genetic, nutrition, physiology, and psychosocial contributors all play a role. [1]
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