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Some 150 years ago, it was an extremely rare disease. In 1878, malignant lung tumors represented only 1% of all cancers seen at autopsy in the Institute of Pathology of the University of Dresden in Germany. By 1918, the percentage had risen to almost 10% and by 1927 to more than 14%.
Lung cancer, disease characterized by uncontrolled growth of cells in the lungs. Lung cancer was first described in the mid-19th century. In the early 20th century it was considered relatively rare, but by the 21st century it had emerged as a leading cause of cancer-related death.
One hundred years ago, lung cancer was a reportable condition and now it accounts for more deaths worldwide from cancer than any other malignant disease. In 1912, Adler published a book entitled Primary Malignant Growths of the Lungs and Bronchi, where he reported all cases of lung cancer in the published literature worldwide.
In the 1950s and 1960s, increasing evidence linked lung cancer and tobacco use, culminating in declarations by most large national health bodies discouraging tobacco use. Early lung cancer often has no symptoms.
As lung cancer incidence increased in mid-20th century, research reports exemplified a descriptive statistical design. The first concept considered in the literature search was that of causation founded within the epidemiological realm; followed by the most common causation element of tobacco.
During the past 250 years, we have witnessed many landmark discoveries in our efforts to make progress against cancer, an affliction known to humanity for thousands of years. This timeline shows a few key milestones in the history of cancer research. 1775: Chimney Soot & Squamous Cell Carcinoma.
In 1912, Isaac Adler published the first literature review about lung cancer. 1 He listed the known 374 cases mentioned in several European registries over the preceding 50 years. Most physicians at the time thought of lung cancer as an extremely rare disease, and Dr. Adler suspected that lung cancer was underdiagnosed.