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Because of this initial approval, oral phenylephrine has stayed in a range of OTC cough and cold medications for nearly 50 years—“even though there are minimal data supporting its ...
Phenylephrine ‘is extensively broken down in the liver, resulting in little to no pharmacological effect’
In fact, a 2021 review of studies published in BMJ Evidence-Based Medicine suggests that honey may actually be "superior to usual care" for improving active symptoms of upper respiratory tract ...
Misuse of multisymptom cold medications, rather than use of a cough suppressant whose sole active ingredient is dextromethorphan, carries significant risk of fatality or serious illness. Multisymptom cold medicines contain other active ingredients, such as paracetamol (acetaminophen), which can cause permanent bodily damage such as kidney ...
[6] [3] A 2014 Cochrane review concluded that "There is no good evidence for or against the effectiveness of OTC [over the counter] medicines in acute cough". [1] Some cough medicines may be no more effective than placebos for acute coughs in adults, including coughs related to upper respiratory tract infections. [7]
There are conflicting studies showing the effectiveness of over-the-counter cold medicine in reducing cold and flu symptoms. A number of studies have found acetaminophen (alone and in combination) to be effective [ 4 ] [ 5 ] and a safe treatment for common cold symptoms such as sore throat and body aches.
There are many cold medicine options. Medical experts say there are several things to know when choosing the best one for you.
A 2016 Cochrane review found insufficient evidence to support the use of intranasal corticosteroids in the relief of common cold symptoms; [2] however, the review was based on three trials and the quality of the evidence was regarded as very low.
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