Search results
Results from the WOW.Com Content Network
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
Testosterone levels with estradiol (E2) alone or in combination with an antiandrogen (AA) in the form of spironolactone (SPL) or cyproterone acetate (CPA) in transfeminine people. [162] Estradiol was used in the form of oral estradiol valerate (EV) in almost all cases. [ 162 ]
Cyproterone is a potent antiandrogen, similarly to CPA. [ 5 ] [ 6 ] However, it has approximately three-fold lower potency as an antagonist of the androgen receptor (AR) relative to CPA. [ 6 ] Like CPA, cyproterone is actually a weak partial agonist of the AR, and hence has the potential for both antiandrogenic and androgenic activity in some ...
Cyproterone acetate, the most widely used steroidal antiandrogen. Main articles: Steroidal antiandrogen and List of steroidal antiandrogens 17α-Hydroxyprogesterone derivatives
The steroidal antiandrogen cyproterone acetate was discovered in 1961. and introduced in 1973. and is often described as the first antiandrogen to have been marketed. [ 191 ] [ 62 ] However, spironolactone was introduced in 1959., [ 192 ] [ 193 ] although its antiandrogen effects were not recognized or taken advantage of until later and were ...
Antiandrogen Relative potency; Bicalutamide: 4.3 Hydroxyflutamide: 3.5 Flutamide: 3.3 Cyproterone acetate: 1.0 Zanoterone: 0.4 Description: Relative potencies of orally administered antiandrogens in antagonizing 0.8 to 1.0 mg/kg s.c. Tooltip subcutaneous injection testosterone propionate-induced ventral prostate weight increase in castrated ...
[17] [4] It also acts as an antiandrogen, or as an antagonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone. [ 17 ] [ 4 ] However, it is thought that the antiandrogenic activity of CPA may only be significant at higher doses than are present in birth control pills.
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.