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In null-hypothesis significance testing, the p-value [note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2] [3] A very small p-value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
The p-value is the probability that a test statistic which is at least as extreme as the one obtained would occur under the null hypothesis. At a significance level of 0.05, a fair coin would be expected to (incorrectly) reject the null hypothesis (that it is fair) in 1 out of 20 tests on average.
The p-value is not the probability that the observed effects were produced by random chance alone. [2] The p-value is computed under the assumption that a certain model, usually the null hypothesis, is true. This means that the p-value is a statement about the relation of the data to that hypothesis. [2]
In 2016, the American Statistical Association (ASA) published a statement on p-values, saying that "the widespread use of 'statistical significance' (generally interpreted as 'p ≤ 0.05') as a license for making a claim of a scientific finding (or implied truth) leads to considerable distortion of the scientific process". [57]
The p-value was introduced by Karl Pearson [6] in the Pearson's chi-squared test, where he defined P (original notation) as the probability that the statistic would be at or above a given level. This is a one-tailed definition, and the chi-squared distribution is asymmetric, only assuming positive or zero values, and has only one tail, the ...
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Under Fisher's method, two small p-values P 1 and P 2 combine to form a smaller p-value.The darkest boundary defines the region where the meta-analysis p-value is below 0.05.. For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0