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In null-hypothesis significance testing, the p-value [note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2] [3] A very small p-value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
The p-value was introduced by Karl Pearson [6] in the Pearson's chi-squared test, where he defined P (original notation) as the probability that the statistic would be at or above a given level. This is a one-tailed definition, and the chi-squared distribution is asymmetric, only assuming positive or zero values, and has only one tail, the ...
The interpretation of a p-value is dependent upon stopping rule and definition of multiple comparison. The former often changes during the course of a study and the latter is unavoidably ambiguous. (i.e. "p values depend on both the (data) observed and on the other possible (data) that might have been observed but weren't"). [69]
In 2016, the American Statistical Association (ASA) published a statement on p-values, saying that "the widespread use of 'statistical significance' (generally interpreted as 'p ≤ 0.05') as a license for making a claim of a scientific finding (or implied truth) leads to considerable distortion of the scientific process". [57]
Under Fisher's method, two small p-values P 1 and P 2 combine to form a smaller p-value.The darkest boundary defines the region where the meta-analysis p-value is below 0.05.. For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0
Note that a p-value of 0.01 suggests that 1% of the time a result at least that extreme would be obtained by chance; if hundreds or thousands of hypotheses (with mutually relatively uncorrelated independent variables) are tested, then one is likely to obtain a p-value less than 0.01 for many null hypotheses.
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The weighted harmonic mean of p-values , …, is defined as = = = /, where , …, are weights that must sum to one, i.e. = =.Equal weights may be chosen, in which case = /.. In general, interpreting the HMP directly as a p-value is anti-conservative, meaning that the false positive rate is higher than expected.