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Xanthine is a product on the pathway of purine degradation. [2] It is created from guanine by guanine deaminase. It is created from hypoxanthine by xanthine oxidoreductase. It is also created from xanthosine by purine nucleoside phosphorylase. Xanthine is subsequently converted to uric acid by the action of the xanthine oxidase enzyme. [2]
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. [4] It is generic and sold under many brand names worldwide.
Xanthine oxidase inhibitors (1 C, 17 P) Pages in category "Xanthines" The following 57 pages are in this category, out of 57 total. This list may not reflect recent ...
Diprophylline [1] or dyphylline (trade names Dilor, Lufyllin) is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. [2] [3]
Doxofylline is a xanthine derivative drug used in the treatment of asthma and chronic obstructive pulmonary disease.
Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects. Pharmacology. It is a phosphodiesterase inhibitor, [1] ...
Febuxostat is a non-purine-selective inhibitor of xanthine oxidase. [14] It works by non-competitively blocking the molybdenum pterin center, which is the active site of xanthine oxidase. Xanthine oxidase is needed to oxidize successively hypoxanthine and xanthine to uric acid. Thus, febuxostat inhibits xanthine oxidase, thereby reducing ...