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[19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...
For example, when the blood pressure drug felodipine is taken with grapefruit juice rather than water, levels of the medication in the blood can more than double and result in headache, irregular ...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
A single report has been made of grapefruit juice possibly increasing the effects of cilostazol; [9] some drug information sources list this as a possible interaction. [10] [11] [12] The FDA-approved labeling of cilostazol notes that grapefruit juice (which is a CYP3A4 inhibitor) increases the drug's maximum concentration by around 50%. [7]
Grapefruit can increase the amount of Cialis in your bloodstream. CYP3A4 (an enzyme in your intestine) is responsible for the metabolism of many drugs, including Cialis. Grapefruit can inhibit CYP3A4.
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
However, eating grapefruit while taking certain prescription medications may cause serious health problems, so check with your doctor or pharmacist before eating grapefruit if you’re taking ...
Levomilnacipran has a high oral bioavailability of 92% and a low plasma protein binding of 22%. [5] [6] It is metabolized in the liver by the cytochrome P450 enzyme CYP3A4, [7] thereby making the medication susceptible to grapefruit-drug interactions.