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Methylphosphonyl dichloride (DC) or dichloro is an organophosphorus compound. It has commercial application in oligonucleotide synthesis, [1] but is most notable as being a precursor to several chemical weapons agents. It is a white crystalline solid that melts slightly above room temperature. [2]
Due to the recycling problem of phosphoryl chloride, SW was adopted in step three of the DMHP process in the preparation of Sarin. [5] SW was also adopted as a standard precursor to V agents, having been used to prepare QL for unitary and binary VX. SW was the first agent adopted to prepare VX in one pot reaction by aqueous medium. [6]
Methylphosphonic acid is an organophosphorus compound with the chemical formula CH 3 P(O)(OH) 2. The phosphorus center is tetrahedral and is bonded to a methyl group, two OH groups and an oxygen. Methylphosphonic acid is a white, non-volatile solid that is poorly soluble in organic solvent but soluble in water and common alcohols.
It will react with thionyl chloride to produce methylphosphonic acid dichloride, which is used in the production of sarin and soman nerve agents. Various amines can be used to catalyse this process. [3] It can be used as a sarin-simulant for the calibration of organophosphorus detectors.
The compound is an intermediate for the synthesis of other chemicals for instance dimethylphenylphosphine: C 6 H 5 PCl 2 + 2 CH 3 MgI → C 6 H 5 P(CH 3) 2 + 2 MgICl. Many tertiary phosphines can be prepared by this route. [3] In the McCormack reaction dichlorophenylphosphine adds dienes to give the chlorophospholenium ring. [4]
The blue isomer is prepared by treating hydrated nickel chloride with triphenylphosphine in alcohols or glacial acetic acid: [1]. NiCl 2 •6H 2 O + 2 PPh 3 → NiCl 2 (PPh 3) 2 + 6 H 2 O ...
Synthesis of [Cp*RhCl 2] 2 using hexamethyl Dewar benzene. This complex was first prepared from hexamethyl Dewar benzene and RhCl 3 (H 2 O) 3 . [ 3 ] [ 4 ] [ 5 ] The hydrohalic acid necessary for the ring-contraction rearrangement is generated in situ in methanolic solutions of the rhodium salt, and the second step has been carried out ...
Dimethylaminophosphorus dichloride is an organophosphorus compound with the formula Me 2 NPCl 2 (Me = methyl). A colorless liquid, it is a reagent in the preparation of other organophosphorus compounds. Many analogous compounds can be prepared from the reactions of secondary amines and phosphorus trichloride: [1] 2 R 2 NH + PCl 3 → R 2 NPCl 2 ...