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Those with the HLA-B27 variant are at a higher risk than the general population of developing the disorder. HLA-B27, demonstrated in a blood test, can occasionally help with diagnosis, but in itself is not diagnostic of AS in a person with back pain. Over 85% of people that have been diagnosed with AS are HLA-B27 positive, although this ratio ...
Among the Sami in Northern Scandinavia , 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis, [3] compared to 14-16% of Northern Scandinavians in general. [ 4 ] [ 5 ] In Finland, an estimated 14% of the population is positive for HLA-B27, while more than 95% of patients with ankylosing spondylitis and ...
HLA-B27 is a polymorphic form of the HLA-B molecule found in up to 95% of people with ankylosing spondylitis of European ancestry, [16] [17] 70% with reactive arthritis, [18] 60% with psoriatic spondylitis, [12] 25% with peripheral psoriatic arthritis, [17] and 70% with spondylitis associated with inflammatory bowel disease. [17] [16]
Ankylosing spondylitis: A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis.
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system Condition Associated HLA allele(s) Fixed drug eruption: B22 Lichen planus: DR1 DR2 DRw9 DR10 Bw15 B8 Psoriasis: Cw6 DR406 Psoriatic arthritis: B27 Ankylosing spondylitis: B27 Reactive arthritis: B27 Acute anterior uveitis: B27 Behçet ...
HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
HLA DR4 is correlated with the genesis of rheumatoid arthritis, type 1 diabetes mellitus, and pemphigus vulgaris. Fewer correlations exist with MHC class I molecules. The most notable and consistent is the association between HLA B27 and spondyloarthropathies like ankylosing spondylitis and reactive arthritis.
HLA-B27 is an example. It is unclear how exactly having the HLA-B27 tissue type increases the risk of ankylosing spondylitis and other associated inflammatory diseases, but mechanisms involving aberrant antigen presentation or T cell activation have been hypothesized.