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Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1] [4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. [5]
Veterinarians and pet owners share their top picks for probiotics for dogs with digestive issues, including supplements for dogs with allergies and diarrhea. If Your Dog Has Stomach Issues, These ...
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H + /K + ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those ...
The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. [ citation needed ] Because the H,K-ATPase is the final step of acid secretion, an inhibitor of this enzyme is more effective than receptor ...
Dexlansoprazole, is a medication which reduces stomach acid. [3] It is used to treat gastroesophageal reflux disease. [3] Effectiveness is similar to other proton pump inhibitors (PPIs). [4] It is taken by mouth. [3] Common side effects include diarrhea, abdominal pain, and nausea. [3]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
The affected dog usually vomits a few hours after consumption and begins showing signs of kidney failure three to five days later. A mycotoxin is suspected to be involved, but one has not been found in grapes or raisins ingested by affected dogs. Salicylate, tartaric acid, or potassium bitartrate have also been implicated. The reason some dogs ...
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