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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  3. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    They have a rapid onset and offset of action. This means it is often possible to pause them 12 to 48 hours before surgery and resume them shortly after the surgery. By contrast, warfarin and phenprocoumon are often paused up to a week before surgery, and low-molecular-weight heparins are used to "bridge" the therapy gap, typically for several ...

  5. Everything you need to know about the Mayo Clinic diet - AOL

    www.aol.com/lifestyle/everything-know-mayo...

    The Mayo Clinic diet, a program that adheres to this notion, was developed by medical professionals based on scientific research, so you can trust that this program is based on science, and not ...

  6. What is the Mayo Clinic Diet — and is it healthy? - AOL

    www.aol.com/news/mayo-clinic-diet-does-154528048...

    The Mayo Clinic diet is consistently ranked as one of the best diets according to U.S New and World Report's rankings, coming in fourth for the overall best diet in the 2022 rankings.

  7. Here's What Experts Think About The The Mayo Clinic Diet - AOL

    www.aol.com/lifestyle/heres-experts-think-mayo...

    The Mayo Clinic diet has two phases during which you can lose up to 10 pounds in two weeks. Here's what to know about it, including the Mayo Clinic Diet menu.

  8. Mayo Clinic Diet - Wikipedia

    en.wikipedia.org/wiki/Mayo_Clinic_Diet

    The Mayo Clinic Diet is a diet book first published in 1949 by the Mayo Clinic's committee on dietetics as the Mayo Clinic Diet Manual. [1] Prior to this, use of the term "diet" was generally connected to fad diets with no association to the clinic.

  9. Diabetes, heart disease cases skyrocket — and scientists ...

    www.aol.com/diabetes-heart-disease-cases...

    New research has found that about 2.2 million new diagnoses of type 2 diabetes and 1.2 million new cases of cardiovascular disease may be attributed to sugar-sweetened sodas and juices each year.