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The UK medicines regulator MHRA warned that fluoroquinolones were linked to rare but occasionally severe and irreversible side effects, including tendon rupture, muscle and joint pain and nerve ...
A 2018 EU-wide review of fluoroquinolones concluded that they are associated with serious side effects including tendonitis, tendon rupture, arthralgia, pain in extremities, gait disturbance, neuropathies associated with paraesthesia, depression, fatigue, memory impairment, sleep disorders, and impaired hearing, vision, taste and smell.
Males are also over 2 times more likely to develop an Achilles tendon rupture as opposed to women. Achilles tendon rupture tends to occur most frequently between the ages of 25-40 and over 60 years of age. Sports and high-impact activity is the most common cause of rupture in younger people, whereas sudden rupture from chronic tendon damage is ...
Among these, tendon problems and exacerbation of the symptoms of the neurological disorder myasthenia gravis are the subject of "black box" warnings in the United States. The most severe form of tendonopathy associated with fluoroquinolone administration is tendon rupture, which in the great majority of cases involves the Achilles tendon.
According to Forbes, there have been 45,000 reported cases of side effects related to fluoroquinolones. 23.1 million patients filled prescriptions for oral flouroquinolones in 2011.
Severe side effects may include spontaneous tendon ruptures, nerve damage, and worsening of myasthenia gravis. [4] Safety of use in pregnancy and breastfeeding is unclear. [6] Moxifloxacin is in the fluoroquinolone family of medications. [4] It usually kills bacteria by blocking their ability to duplicate DNA. [4]
One study found that fluoroquinolone use was associated with a 1.9-fold increase in tendon problems. The risk increased to 3.2 in those over 60 years of age and to 6.2 in those over the age of 60 who were also taking corticosteroids. Among the 46,766 quinolone users in the study, 38 (0.08%) cases of Achilles tendon rupture were identified. [59]
[9] Rarely, tendinitis or tendon rupture may occur due to fluoroquinolone antibiotics, including levofloxacin. [43] Such injuries, including tendon rupture, has been observed up to six months after cessation of treatment; higher doses of fluoroquinolones, being elderly, transplant patients, and those with a current or historical corticosteroid ...