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It contains clindamycin, as the phosphate, a lincosamide antibacterial; adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent. [2] It is applied to the skin . [ 2 ]
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6] Studies have found adapalene is as effective as other retinoids, while causing less irritation. [7]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
Clindamycin/benzoyl peroxide, sold under the brand name Benzaclin among others, is a topical gel used for the treatment of acne. [7] It is a fixed-dose combination of clindamycin, as the phosphate, an antibiotic; and benzoyl peroxide, an antiseptic.
In the United States, due to vehicles being larger on average than some other countries, [4] a parking space 10 feet (3.0 m) deep is uncommon and most parking spaces will be within 16 to 20 feet (4.9–6.1 m), with 19 feet (5.8 m) feet deep being the standard DOT recommended depth for standard perpendicular parking.
[2] [3] It is primarily used for the treatment of plaque psoriasis and acne. [4] Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. [4] It is a member of the acetylenic class of retinoids. [4] Tazarotene was approved for medical use in 1997 [5] and is available as a generic medication. [6] [7]
As an anti-inflammatory, dapsone inhibits the myeloperoxidase-H 2 O 2-halide-mediated cytotoxic system in polymorphonucleocytes. [50] As part of the respiratory burst that neutrophils use to kill bacteria, myeloperoxidase converts hydrogen peroxide (H 2 O 2) into hypochlorous acid (HOCl). HOCl is the most potent oxidant generated by neutrophils ...
Parallel parking is a method of parking a vehicle parallel to the road, in line with other parked vehicles. Parallel parking usually requires initially driving slightly past the parking space, parallel to the parked vehicle in front of that space, keeping a safe distance, then followed by reversing into that space. Subsequent position ...