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  2. Potassium chloride (medical use) - Wikipedia

    en.wikipedia.org/wiki/Potassium_chloride...

    Potassium chloride, also known as potassium salt, is used as a medication to treat and prevent low blood potassium. [2] Low blood potassium may occur due to vomiting, diarrhea, or certain medications. [3] The concentrated version should be diluted before use. [2] It is given by slow injection into a vein or by mouth. [4]

  3. Potassium channel blocker - Wikipedia

    en.wikipedia.org/wiki/Potassium_channel_blocker

    Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.

  4. Drug interaction - Wikipedia

    en.wikipedia.org/wiki/Drug_interaction

    When two drugs affect each other, it is a drugdrug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drugdrug interactions. [2] Drug interactions can be of three kinds ...

  5. Additive effect - Wikipedia

    en.wikipedia.org/wiki/Additive_effect

    It was introduced by the scientists in pharmacology and biochemistry fields in the process of understanding the synergistic interaction between drugs and chemicals over the century. Additive effect often occurs when two similar drugs are taken together to achieve the same degree of therapeutic effect while reducing the specific adverse effect ...

  6. Amiloride - Wikipedia

    en.wikipedia.org/wiki/Amiloride

    Amiloride was the only drug in the screen that was capable of causing the excretion of sodium (natriuresis) without a concomitant urinary excretion of potassium (kaliuresis). [27] Thousands of amiloride analogues have been studied since its initial discovery, which have been used to study the effects of sodium transporters.

  7. Azilsartan - Wikipedia

    en.wikipedia.org/wiki/Azilsartan

    No relevant drug interactions have been found in studies. [ 8 ] [ 9 ] Based on experiences with other drugs acting on the renin–angiotensin system, it is theorized that azilsartan could increase the toxicity of lithium and of other drugs increasing potassium levels, such as potassium sparing diuretics .

  8. Drug action - Wikipedia

    en.wikipedia.org/wiki/Drug_action

    The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.

  9. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of_spiro...

    Hence, aldosterone antagonists are potassium (K +) sparing diuretics. The medication has a slightly delayed onset of action, and so it takes several days for diuresis to occur since the MR is a nuclear receptor which works through regulating gene transcription and gene expression.

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