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Ezetimibe/rosuvastatin, sold under the brand name Ridutrin among others, is a combination medication used to treat high cholesterol. [6] [7] In some countries it is sold as a kit or a pack containing two distinct pills. [8] [9] The combination was approved for medical use in the United States in March 2021. [4]
Within 4–12 hours of the oral administration of a 10-mg dose to fasting adults, the attained mean ezetimibe peak plasma concentration (C max) was 3.4–5.5 ng/ml. Following oral administration, ezetimibe is absorbed and extensively conjugated to a phenolic glucuronide (active metabolite).
Managing cholesterol at the site of absorption is an increasingly popular strategy in the treatment of hypercholesterolemia [citation needed].Cholesterol absorption inhibitors are known to have a synergistic effect when combined a class of antihyperlipidemics called statins, to achieve an overall serum cholesterol target.
Absolute bioavailability of rosuvastatin is about 20% and C max is reached in 3 to 5 hours; administration with food did not affect the AUC according to the original sponsor submitted clinical study and as per product label. [4] However, a subsequent clinical study has shown a marked reduction in rosuvastatin exposure when administered with ...
Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut, so they are most effective when consumed with meals. However, their precise mechanism of action differs from ezetimibe. Omega-3 supplements taken at high doses can reduce levels of triglycerides. [6] They are associated with a very modest increase in LDL (~5% ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...
C10BA05 Atorvastatin and ezetimibe C10BA06 Rosuvastatin and ezetimibe C10BA07 Rosuvastatin and omega-3 fatty acids C10BA08 Atorvastatin and omega-3 fatty acids C10BA09 Rosuvastatin and fenofibrate C10BA10 Bempedoic acid and ezetimibe C10BA11 Pravastatin and ezetimibe C10BA12 Pravastatin, ezetimibe and fenofibrate C10BA13 Pitavastatin and ezetimibe