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Interleukin 3 is an interleukin, a type of biological signal that can improve the body's natural response to disease as part of the immune system. [10] In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor.
The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes .
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
IL-17A specifically targets keratinocytes and is the major cytokine causing pathogenesis of skin psoriasis. [18] In addition, IL-17A is also expressed to an increasing extent in patients with inflammatory bowel disease. [19] ILC 3 may play a role already in the prenatal setting of the body's resistance to infections.
[3] nILC2s are those responsive to IL-33 in tissues in a natural immune state, while iILC2s respond to IL-25 or the helminth parasite. [3] nILC2s express more Thy1 and ST2, and reduced KLRG1. [3] iILC2s, express more KLRG1, and reduced Thy1 and ST2. [3] In addition to these subpopulations, another population, named the ILC210 cell, is ...
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Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...
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