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Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. [2] [3] Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types.
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration , asexual reproduction , metamorphosis , and the growth and differentiation of stem cells in the adult organism.
Germ-Soma Differentiation is the process by which organisms develop distinct germline and somatic cells. The development of cell differentiation has been one of the critical aspects of the evolution of multicellularity and sexual reproduction in organisms.
B: Nerve cells, an example of a cell type after differentiation. Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell. [15] Totipotent (also known as omnipotent) stem cells can differentiate into embryonic and extraembryonic cell types.
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
Epigenetics is known to be important in the regulation of gene expression of differentiation. As such, studies done on small molecules or drugs that inhibit epigenetic mechanisms during differentiation can have great potential for clinical applications such as bone regeneration from mesenchymal stem cells. [15]
Genetic distance is a measure of the genetic divergence between species or between populations within a species, whether the distance measures time from common ancestor or degree of differentiation. [2] Populations with many similar alleles have small genetic distances. This indicates that they are closely related and have a recent common ancestor.
Differentiation, a peer-reviewed academic journal covering cell differentiation and cell development Developmental biology , the study of the process by which animals and plants grow and develop Differentiation therapy , a cancer treatment in which malignant cells are encouraged to differentiate into more mature forms using pharmacological agents