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Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. [2] [3] Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types.
Directed differentiation is a bioengineering methodology at the interface of stem cell biology, developmental biology and tissue engineering. [1] It is essentially harnessing the potential of stem cells by constraining their differentiation in vitro toward a specific cell type or tissue of interest. [ 2 ]
They hypothesized that each lump (colony) was a clone arising from a single marrow cell (stem cell). In subsequent work, McCulloch and Till, joined by graduate student Andrew John Becker and senior scientist Louis Siminovitch, confirmed that each lump did in fact arise from a single cell
Germ-Soma Differentiation is the process by which organisms develop distinct germline and somatic cells. The development of cell differentiation has been one of the critical aspects of the evolution of multicellularity and sexual reproduction in organisms.
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration , asexual reproduction , metamorphosis , and the growth and differentiation of stem cells in the adult organism.
Epigenetics is known to be important in the regulation of gene expression of differentiation. As such, studies done on small molecules or drugs that inhibit epigenetic mechanisms during differentiation can have great potential for clinical applications such as bone regeneration from mesenchymal stem cells. [15]
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
In the field of developmental biology, regional differentiation is the process by which different areas are identified in the development of the early embryo. [1] The process by which the cells become specified differs between organisms .