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Intestinal metaplasia is the transformation of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine. In the esophagus, this is called Barrett's esophagus .
It begins with normal tissue and long-term inflammation causes the cells to undergo atrophy, metaplasia, dysplasia, and finally, becomes an adenoma or carcinoma. [2] Given this progression, these lesions represent a potentially cancerous growths and an important opportunity to prevent gastrointestinal cancer.
Micrograph showing apocrine metaplasia of the breast with typical features [3] H&E stain. Barrett's esophagus is an abnormal change in the cells of the lower esophagus, thought to be caused by damage from chronic stomach acid exposure. The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the ...
UV light from solar radiation causes DNA damage that is important in melanoma. [21] Helicobacter pylori infection produces high levels of reactive oxygen species that damage DNA and contributes to gastric cancer. [22] Bile acids, at high levels in the colons of humans eating a high fat diet, also cause DNA damage and contribute to colon cancer ...
Colon cancer is the second-leading cause of cancer deaths in the United States and is expected to kill more than 53,000 people in the nation in 2024, according to the American Cancer Society.
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). [5] Signs and symptoms may include blood in the stool , a change in bowel movements , weight loss, abdominal pain and fatigue. [ 9 ]
Cancers on the right side of the large intestine (ascending colon and cecum) tend to be exophytic, that is, the tumor grows outwards from one location in the bowel wall. This very rarely causes obstruction of feces, and presents with symptoms such as anemia. Left-sided tumors tend to be circumferential, and can obstruct the bowel lumen, much ...
Rectal bleeding is less common than in ulcerative colitis, and is more likely to occur with inflammation in the colon or rectum. Bleeding in the colon or rectum is bright red, whereas bleeding in higher segments causes dark or black stools. [9] Bloating, flatus, and other symptoms of irritable bowel syndrome occur in 41% of people in remission ...
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