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While it is unclear if use during pregnancy carries potential for fetal harm, treating malaria during pregnancy with quinine when appropriate is still recommended. [5] Quinine is an alkaloid, a naturally occurring chemical compound. [5] How it works as a medicine is not entirely clear. [5]
Primaquine is a medication used to treat and prevent malaria and to treat Pneumocystis pneumonia. [2] Specifically it is used for malaria due to Plasmodium vivax and Plasmodium ovale along with other medications and for prevention if other options cannot be used. [2] It is an alternative treatment for Pneumocystis pneumonia together with ...
Quinidine is a class IA antiarrhythmic agent used to treat heart rhythm disturbances. [1] It is a diastereomer of antimalarial agent quinine, [2] originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. As of 2019, its IV formulation is no longer being ...
Quinine sulfate 300 to 325 mg once daily: this regimen is effective but not routinely used because of the unpleasant side effects of quinine. Prophylaxis against Plasmodium vivax requires a different approach given the long liver stage of this parasite. [11] This is a highly specialist area.
Additionally, there are significant side effects with quinine ('cinchonism') and tetracyclines are contraindicated in children and pregnant women (these groups should use clindamycin instead). With the advent of artemisinin-combination therapies, quinine-based treatment is less popular than previously.
Its principal use is as a precursor to 8-hydroxyquinoline, which is a versatile chelating agent and precursor to pesticides. Its 2- and 4-methyl derivatives are precursors to cyanine dyes . Oxidation of quinoline affords quinolinic acid (pyridine-2,3-dicarboxylic acid), a precursor to the herbicide sold under the name "Assert".
Concomitant use with drugs containing quinidine, quinine, or mefloquine; Concomitant use with drugs that both prolong the QT interval and are metabolized by CYP2D6 (e.g., thioridazine, pimozide); effects on QT interval may be increased; Concomitant use with MAOIs or use of MAOIs within 14 days; risk of serious, potentially fatal, drug ...
In 1633, this herbal medicine was introduced in Europe, where it was given the same use and also began to be used against malaria. The quinoline antimalarial drug quinine was isolated from the extract in 1820. [49]: 130–131 3-Methylchloroquine (sontochin) After World War I, the German government sought alternatives to quinine.