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The relevant platelet activity is termed platelet factor 3 (PF3), and results from the combined effects of surface membrane microvesiculation; expression of procoagulant phospholipids (phosphatidylserine, phosphatidylinositol); and receptor-mediated interactions between platelets and coagulation proteins [13,14].
Tissue factor, also called platelet tissue factor or Coagulation factor III, [5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene.
Platelet Factor 3 — Properties and Clinical Significance. In: Mannucci, P.M., Gorini, S. (eds) Platelet Function and Thrombosis. Advances in Experimental Medicine and Biology, vol 34.
This topic summarizes available platelet function tests and provides information about how to interpret the results of platelet function testing. Separate topics discuss a general approach to evaluating unexplained bleeding and the evaluation and management of specific platelet function disorders:
Platelets’ involvement in coagulation and the resulting formation of a platelet plug during damage to blood vessels is a result of a wide variety of factors released from the α-granules (Table 1), dense granules (Table 2), and lysosomes (Table 3) contained within the platelet.
Platelets are small blood cells with several physiological purposes; the best studied is thrombosis activation. Through their clotting activity and activation of the coagulation cascade, they are crucial to maintaining adequate blood volume in those with vascular injury.
Platelet Factor 3. Platelet factor 3 (PF3) is a platelet membrane component that plays an important role in the activation of the coagulation mechanism. Whenever platelet activation occurred, PF3 is released and participates in thrombin formation.