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Samples can be harvested for analysis from these models from any compartment at any time. TIM-2 simulates the colon, containing the microbiota as found in human colon. This model serves as a tool to study fermentation of non-digestible food components (fibers and prebiotics) and the release of drugs specifically targeted for the colon. [9]
MNase digestion of chromatin was key to early studies of chromatin structure; being used to determine that each nucleosomal unit of chromatin was composed of approximately 200bp of DNA. [13] This, alongside Olins’ and Olins’ “beads on a string” model, [14] confirmed Kornberg’s ideas regarding the basic chromatin structure. [15]
The model equations follow the principles of mass transport, fluid dynamics, and biochemistry in order to simulate the fate of a substance in the body. [9] Compartments are usually defined by grouping organs or tissues with similar blood perfusion rate and lipid content (i.e. organs for which chemicals' concentration vs. time profiles will be similar).
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The DRM went largely unnoticed, but a recent paper by Van Gils [2] describes how red knots Calidris canutus forage based on digestive bottlenecks and confirmed their foraging according to the DRM rather than the CM model of optimal foraging. The case is particularly interesting as a major difference in individual foraging behavior is related to ...
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