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Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as atopic dermatitis (eczema), asthma and nasal polyps which result in chronic sinusitis. [6] [7] [8] [4] It is also used for the treatment of eosinophilic esophagitis, [9] prurigo nodularis [10] and ...
It can be caused by anatomical factors such as a deviated septum or nasal polyps (growths), as well as infection. Symptoms include difficulty breathing through the nose, swelling and pain around the nose and eyes, postnasal drainage down the throat, and difficulty sleeping. [10] CRS is a common condition in children and young adults. [11]
There is only limited evidence to support short treatment with corticosteroids by mouth for chronic rhinosinusitis with nasal polyps. [91] [92] [93] There is limited evidence to support corticosteroids by mouth in combination with antibiotics for acute sinusitis; it has only short-term effect improving the symptoms. [94] [95]
Acute sinusitis lasts a maximum of 12 weeks. The clinical symptoms of acute rhinosinusitis are purulent nasal secretion, nasal obstruction and/or tension headache or feeling of fullness in the facial area. Acute rhinosinusitis can be caused by a viral or bacterial infection – a distinction is not possible during the first days.
Nasal polyps resulting from chronic rhinosinusitis affect approximately 4.3% of the population. [6] Nasal polyps occur more frequently in men than women and are more common as people get older, increasing drastically after the age of 40. [6] Of people with chronic rhinosinusitis, 10% to 54% also have allergies.
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