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In patients where MRI is contraindicated (certain implantable devices, certain kidney conditions) or in those who prefer to avoid MRI (claustrophobia), molecular breast imaging is a viable alternative. MBI has shown to increase detection of breast cancer in dense breasts by 7-16 cancers per 1000 screens. [1] [3] [5]
The largest (Hellquist et al) [97] and longest running (Tabar et al) [98] breast cancer screening studies in history re-confirmed that regular mammography screening cut breast cancer deaths by roughly a third in all women ages 40 and over (including women ages 40–49). This renders the USPSTF calculations off by half.
MRI breasts has the highest sensitivity to detect breast cancer when compared with other imaging modalities such as breast ultrasound or mammography. In the screening for breast cancer for high-risk women, sensitivity of MRI range from 83 to 94% while specificity (the confidence that a lesion is cancerous and not a false positive ) range from ...
Breast MRI is not recommended for screening all breast cancer patients, yet limited to patients with high risk of developing breast cancer that may have high familial risk or mutations in BCRA1/2 genes. [51] Breast MRI is not a perfect tool despite its increased sensitivity for detecting breast cancer masses when compared to mammography.
Breast MRI is a technology typically reserved for high-risk patients and patients recently diagnosed with breast cancer. [3] Lastly, scintimammography is used in a subgroup of patients who have abnormal mammograms or whose screening is not reliable on the basis of using traditional mammography or ultrasound.
The tissue makes it harder to find tumors while doing a mammogram, therefore MRI screening is proposed to supplement the mammogram in these patients. [24] Like other cancers there are advantages and disadvantages to screening for breast cancer, with risks of harm by overdiagnosis, a possibility of radiation-induced cancer and false positives.
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Positron emission mammography (PEM) is a nuclear medicine imaging modality used to detect or characterise breast cancer. [1] Mammography typically refers to x-ray imaging of the breast, while PEM uses an injected positron emitting isotope and a dedicated scanner to locate breast tumors.