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Hemosiderin image of a kidney viewed under a microscope. The brown areas represent hemosiderin. Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin ...
Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Red blood cell extravasation and deposition of hemosiderin that follows clinically appear as hyperpigmentation, which can occur in a reticular distribution. It has also been proposed that the distribution of affected blood vessels—predominantly in the superficial subcutaneous plexus (found in the papillary dermis )—results in the net-like ...
6. Purple spots on your hands and feet. These could be a sign of a bacterial infection of the heart, Kroshinsky said. 7. A circular-shaped rash in an area where Lyme disease is endemic.
Rosacea. What it looks like: Rosacea causes redness and thick skin on the face, usually clustered in the center.Easy flushing, a stinging sensation, and small, pus-filled pimples are other common ...
What it looks like: Psoriasis, another inflammatory condition that dermatologists see frequently, is known to causes scaly, itchy areas of thickened skin called plaques that can look like rashes.
[5] [8] [14] Later stages show significant hemosiderin deposition in the stroma, fibrosis, and a collapsed appearance of the arterial lumen. [8] [14] Clinical differential diagnoses include infantile hemangioma, melanocytic lesions, tufted angioma, insect bite, Kaposi sarcoma, erythema multiforme, and dermatofibroma, depending on the stage of ...
Hemosiderin deposition in the lungs is often seen after diffuse alveolar hemorrhage, which occurs in diseases such as Goodpasture's syndrome, granulomatosis with polyangiitis, and idiopathic pulmonary hemosiderosis. Mitral stenosis can also lead to pulmonary hemosiderosis. Hemosiderin collects throughout the body in hemochromatosis.
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