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Some interactions may be due to the pH increase observed in the stomach following antacid ingestion, leading to increased absorption of weak acids, and decreased absorption of weak bases. [citation needed] Antacids also cause an increase in pH of the urine (alkalization), which may cause increased blood concentrations of weak bases, and ...
A strong base is a basic chemical compound that can remove a proton (H +) from (or deprotonate) a molecule of even a very weak acid (such as water) in an acid–base reaction. Common examples of strong bases include hydroxides of alkali metals and alkaline earth metals, like NaOH and Ca(OH)
For example, acetic acid is a weak acid which has a = 1.75 x 10 −5. Its conjugate base is the acetate ion with K b = 10 −14 /K a = 5.7 x 10 −10 (from the relationship K a × K b = 10 −14), which certainly does not correspond to a strong base. The conjugate of a weak acid is often a weak base and vice versa.
As an antacid, magnesium hydroxide is dosed at approximately 0.5–1.5 g in adults and works by simple neutralization, in which the hydroxide ions from the Mg(OH) 2 combine with acidic H + ions (or hydronium ions) produced in the form of hydrochloric acid by parietal cells in the stomach, to produce water.
An acid-base diagram for human plasma, showing the effects on the plasma pH when P CO 2 in mmHg or Standard Base Excess (SBE) occur in excess or are deficient in the plasma [23] Acid–base imbalance occurs when a significant insult causes the blood pH to shift out of the normal range (7.32 to 7.42 [16]).
The position of equilibrium varies from base to base when a weak base reacts with water. The further to the left it is, the weaker the base. [5] When there is a hydrogen ion gradient between two sides of the biological membrane, the concentration of some weak bases are focused on only one side of the membrane. [6]
A weak acid cannot always be neutralized by a weak base, and vice versa. However, for the neutralization of benzoic acid (K a,A = 6.5 × 10 −5) with ammonia (K a,B = 5.6 × 10 −10 for ammonium), K = 1.2 × 10 5 >> 1, and more than 99% of the benzoic acid is converted to benzoate.
Weak antacid properties In vitro and in vivo data have shown that bismuth subsalicylate hydrolyzes in the gut to bismuth oxychloride and salicylic acid and less commonly bismuth hydroxide . In the stomach, this is likely an acid-catalyzed hydrolysis.
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