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A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
Chondroitin sulfate; Dermatan sulfate; Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine ...
Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. [citation needed] Glucosamine, along with commonly used chondroitin, is not routinely prescribed to treat people who have symptomatic osteoarthritis of the knee, as there is insufficient evidence that this treatment is helpful ...
Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin-4-sulfate: R 1 = H; R 2 = SO 3 H; R 3 = H. Chondroitin-6-sulfate: R 1 = SO 3 H; R 2, R 3 = H.. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
The repeating disaccharide unit (GlcUA(1β→3)GalNAc(1β→4)) n of chondroitin sulfate. For polysaccharide nomenclature see here. R 1, R 2, R 3 may have different values. Glycosaminoglycans [1] (GAGs) or mucopolysaccharides [2] are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units).
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Despite the difficulty in determining the efficacy of glucosamine, it remains a treatment option. [163] The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends glucosamine sulfate and chondroitin sulfate for knee osteoarthritis. [164] Its use as a therapy for osteoarthritis is usually safe ...
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