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Hydroxyurea was the first approved drug for the treatment of SCD, which has been shown to decrease the number and severity of attacks and possibly increase survival time. [ 95 ] [ 96 ] This is achieved, in part, by reactivating fetal haemoglobin production in place of the haemoglobin S that causes sickling.
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The human immunodeficiency virus (HIV) [8] [9] [10] is a retrovirus [11] that attacks the immune system.It is a preventable disease. [5] There is no vaccine or cure for HIV. It can be managed with treatment and become a manageable chronic health condition. [5]
Inhalation of nitrous oxide is used frequently to relieve pain associated with childbirth, trauma, oral surgery and acute coronary syndrome (including heart attacks). Its use during labour has been shown to be a safe and effective aid for birthing women. [95] Its use for acute coronary syndrome is of unknown benefit. [96]
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Although rare in young children with severe malaria, acute respiratory distress syndrome occurs in 5–25% of adults and up to 29% of pregnant women. [41] Coinfection of HIV with malaria increases mortality. [42] Kidney failure is a feature of blackwater fever, where haemoglobin from lysed red blood cells leaks into the urine. [36]
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