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The human cerebellum is located at the base of the brain, with the large mass of the cerebrum above it, and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of tough dura mater called the cerebellar tentorium; all of its connections with other parts of the brain travel through the pons.
It receives input exclusively from the cerebral cortex (especially the parietal lobe) via the pontine nuclei (forming cortico-ponto-cerebellar pathways), and sends output mainly to the ventrolateral thalamus (in turn connected to motor areas of the premotor cortex and primary motor area of the cerebral cortex) and to the red nucleus. [14]
The cerebral cortex, also known as the cerebral mantle, [1] is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals.It is the largest site of neural integration in the central nervous system, [2] and plays a key role in attention, perception, awareness, thought, memory, language, and consciousness.
They develop in the cerebellar primordium that covers the fourth ventricle and below a fissure-like region called the isthmus of the developing brain. Purkinje cells migrate toward the outer surface of the cerebellar cortex and form the Purkinje cell layer. Purkinje cells are born during the earliest stages of cerebellar neurogenesis.
The cerebellum is divided into an anterior lobe, a posterior lobe, and the flocculonodular lobe. [32] The anterior and posterior lobes are connected in the middle by the vermis. [33] Compared to the cerebral cortex, the cerebellum has a much thinner outer cortex that is narrowly furrowed into numerous curved transverse fissures. [33]
The superior colliculus, which plays a major role in visual control of behavior in most vertebrates, shrinks to a small size in mammals, and many of its functions are taken over by visual areas of the cerebral cortex. [60] The cerebellum of mammals contains a large portion (the neocerebellum) dedicated to supporting the cerebral cortex, which ...
The cerebellar nuclei receive afferent projections from the inferior olive, lateral reticular nucleus, upper cervical and lumbar spinal segments, and the Pontine nuclei. Together, the deep cerebellar nuclei form a functional unit that provides feedback control of the cerebellar cortex by cerebellar output. [4]
The loop involves connections between the cortex, the basal ganglia, the thalamus, and back to the cortex. It is of particular relevance to hyperkinetic and hypokinetic movement disorders , such as Parkinson's disease and Huntington's disease , [ 1 ] as well as to mental disorders of control, such as attention deficit hyperactivity disorder ...