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Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness. [1] Caused by human cytomegalovirus , it occurs predominantly in people whose immune system has been compromised, including 15-40% of those with AIDS.
CMV reactivation is commonly seen in people with severe colitis. [39] Specific disease entities recognized in those people are CMV hepatitis, which may cause fulminant liver failure; cytomegalovirus retinitis (inflammation of the retina, characterised by a "pizza pie appearance" on ophthalmoscopy) cytomegalovirus colitis (inflammation of the ...
Retinitis may be caused by several infectious agents, including toxoplasmosis, [1] cytomegalovirus and candida. [2] Cytomegalovirus retinitis is an important cause of blindness in AIDS patients. [2] Candida spreading to the retina from the bloodstream usually results in the production of several retinal abscesses. [2]
Cytomegalovirus (CMV) (from cyto-'cell' via Greek κύτος kútos - 'container' + μέγας mégas 'big, megalo-' + -virus via Latin vīrus 'poison') is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, [3] in the subfamily Betaherpesvirinae. Humans and other primates serve as natural hosts.
Chorioretinitis is often caused by toxoplasmosis and cytomegalovirus infections (mostly seen in immunodeficient subjects such as people with HIV/AIDS or on immunosuppressant drugs). [3] Congenital toxoplasmosis via transplacental transmission can also lead to sequelae such as chorioretinitis along with hydrocephalus and cerebral calcifications.
Cidofovir, brand name Vistide, is a topical or injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis (an infection of the retina of the eye) in people with AIDS. [4] [5] Cidofovir was approved for medical use in 1996. [6]
Fomivirsen (brand name Vitravene) is an antisense antiviral drug that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It was administered via intraocular injection.
Cytomegalovirus (CMV) Retinitis: This is an inflammation of the retina caused by infection, which can result in blindness. It occurs in people experiencing suppressed immune systems , most commonly by Acquired Immunodeficiency Syndrome (AIDS) .