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Claudication, from Latin claudicare 'to limp', refers to painful cramping or weakness in the legs. [3] NC should therefore be distinguished from vascular claudication, which stems from a circulatory problem rather than a neural one. The term neurogenic claudication is sometimes used interchangeably with spinal stenosis.
Spinal or neurogenic claudication may be differentiated from arterial claudication based on activity and position. In neurogenic claudication, positional changes lead to increased stenosis (narrowing) of the spinal canal and compression of nerve roots and resultant lower extremity symptoms. Standing and extension of the spine narrows the spinal ...
Magnesium deficiency causes neurogenic inflammation in a rat model. Researchers have theorized that since substance P which appears at day five of induced magnesium deficiency, is known to stimulate in turn the production of other inflammatory cytokines including IL-1, Interleukin 6 (IL-6), and TNF-alpha (TNFα), which begin a sharp rise at day 12, substance P is a key in the path from ...
Vascular claudication can resemble spinal stenosis, and some individuals experience unilateral or bilateral symptoms radiating down the legs rather than true claudication. [7] The first symptoms of stenosis include bouts of low back pain. After a few months or years, this may progress to claudication.
Neurogenic claudication can occur in cases of severe lumbar spinal stenosis and presents with symptoms of pain in the lower back, buttock or leg that is worsened by standing and relieved by sitting. Vertebral compression fractures occur in four percent of patients presenting with lower back pain. [26]
IPD's were developed for patients who have lumbar spinal stenosis, suffer symptoms of neurogenic intermittent claudication, and who are able to relieve their symptoms when they bend forward or flex their spines. [1]
Intermittent neurogenic claudication [17] [20] [21] characterized by lower limb numbness, weakness, diffuse or radicular leg pain associated with paresthesia (bilaterally), [20] weakness and/or heaviness in buttocks radiating into lower extremities with walking or prolonged standing. [17]
Intermittent claudication is a symptom and is by definition diagnosed by a patient reporting a history of leg pain with walking relieved by rest. However, as other conditions such as sciatica can mimic intermittent claudication, testing is often performed to confirm the diagnosis of peripheral artery disease .